Source

The seed of the Strychnos nux vomica, which contains two alkaloids, strychnine and brucine, the amount of strychnine being one-fourth to one-half per cent., and of brucine from one-eighth to one per cent.

Strychnine

Strychnina (C21H22N2O2) - is a white or grayish 31 white powder of a very bitter taste, almost insoluble in water, and very soluble in boiling alcohol.

Sulphate Of Strychnine

Strychninae Sulphas - is a white salt in the form of colorless prismatic crystals, which are very bitter and odorless, soluble in ten parts of water, somewhat so in alcohol, but insoluble in ether.

Medical Properties And Therapeutic Uses

Nux vomica and strychnine are bitter stomachic and muscular tonics. In small doses strychnine increases the gastro-intestinal secretions, hastens intestinal movements, and elevates arterial tension. In larger doses the pupils are dilated and the muscles spasmodically contracted. Poisonous doses cause muscular tremors, intermittent tetanic spasms, and death from rigidity of the respiratory muscles, without any impairment of the mind.

Poisonous quantities of strychnine accumulate in the system, on account of the agent being slowly excreted, from very small doses frequently administered. The antidotes are free evacuation of the stomach, vegetable astringents to precipitate the strychnine, and the inhalation of ether or chloroform, and the hypodermic injection of chloral. Strychnine is employed in anemia, atonic dyspepsia, constipation, vomiting of pregnancy, gastralgia, gastric catarrh, etc., of drunkards, chlorosis, purpura, hemorrhagic diathesis, local paralysis, poisoning by lead, spasmodic asthma, etc., etc. Nux vomica is an antidote to chloral, and is used in intermittent fever as an adjunct to quinine. Brucine is much weaker than strychnine, but similar in its action, and the pure agent is analogous to cocaine, possessing local anaesthetic properties. For hypodermic injection it is resorted to in paraplegia, infantile paralysis, facial paralysis, etc., and also in diseases of the eye, and infraorbital paralysis. A half grain of strychnine has produced a fatal result, and one-twelfth of a grain will produce muscular twitchings, and one-sixteenth of a grain has proved fatal in the case of a child.

Dose

Of Abstractum nucis vomicae, gr. 1/2; of Extractum nucis vomicae, gr. 1/8 to gr. 1/2; of Extractum nucis vomica fluidum, m j to v; of Tinctura nucis vomicae, m v to x; of Strychnina, gr. 1/60 to 1/20; of Strychninae Sulphas, gr. 1/60 to 1/30; of Brucine, gr. to 1/3.

Dental Formula

For Neuralgia.

Ext. nucis vom..................gr.v

Zinci valerian .................

Ext. gentianae.................

Fiat pill No. XX. Signa. - One pill 3 or 4 times a day.

Dental Formula 1237Dental Formula 1238