According to the present knowledge of this subject, inflammation terminates - 1st, By Resolution; 2d, By Suppuration; 3d, By Formation of New Tissue; 4th, By Gangrene or Local Death - Necrosis. When the inflammatory process terminates by resolution, all of the symptoms gradually diminish and disappear, and the affected tissues resume their normal condition. Such a result is generally due to the mild character of the injury, and the progress of the inflammation. Resolution is the most favorable ending of inflammation and is established as soon as the blood which circulates through the vessels restores their walls to a healthy state.

When the inflammatory process terminates by suppuration, there is a loss of substance, and after the discharge of the pus, a more extensive process of repair is required to produce a healing of the wound by the growth of granulation tissue, and the formation of the cicatrix. (See Suppuration and Abscess.)

When the inflammatory process terminates by the formation of new tissue, the new growth is produced by inflammation - either by the union by first intention, or by the development of granulations, which become organized into a cicatrix.

When the inflammatory process terminates in gangrene or local death, the effort of the inflammation toward repair has failed, either on account of the functions of the capillaries and the connective tissue becoming impeded to such a degree as to render inoperative the resources of the organisms, or because of certain conditions arising at a later period which have obstructed the reparative effort and caused the parts to lose their vitality.

The termination of the inflammatory process by gangrene depends upon the degree and nature of the lesion, and the inability of the capillaries and arteries to maintain the local circulation. The impairment of the vitality of the blood vessels causes stasis and thrombosis to occur, and as soon as actual death takes place, the dead tissue presents a further obstacle to the local circulation, and also adds to the difficulty of elimination, which favors the spread of the gangrene. The earliest symptoms of gangrene are hard swelling, burning and tensive pain, and livid color. The pain then subsides, vesications appear, the part takes on a marbled, purplish-yellow color, afterward becoming brown or grayish, and finally cold and insensible, exhaling a putrid odor. (See Gangrene, Necrosis of Bone, and Caries of Bone.)