This malady, even if primarily dependent on calcareous or other degeneration, is mainly a neurosis, and nearly -100 years ago was successfully treated with arsenious acid by Alexander. Philipp and others record very striking benefit in cases that had been rebellious to quinine (Sydenham Society's Year Book, 1865-66), and I can fully bear out Dr. Anstie's testimony to the great relief given by arsenic to patients suddenly attacked with spasmodic pain, embarrassed heart-action, and sense of impending death: he found the medicine reduce the severe attacks to little more than a tightness of the chest, and it availed most in anaemic patients, suffering from overwork and anxiety. (Reference may also be made to cases in Berlin. Klin. Woch., 18G5, and Archives Gen., 1863.)