Cardiac pain and dyspnoea may often be relieved by iron preparations, which act probably in an indirect manner - i.e., by improving the blood in the first instance, hence their advantage is seen most in cases of anaemia: in such conditions, occurring after acute rheumatism, even the physical signs - murmurs, etc. - may improve under a course of iron (Jones: Medical Times, 1861). Increased frequency of pulse is not, in itself, a contra-indication, but only when increase of tension is also detected. In mitral disease with dropsy, the acetate or perchloride is especially useful if combined with diuretics: in fatty degeneration of the heart, in any form of chronic valvular disease, and in dilatation, iron is often serviceable, especially when combined with digitalis.