In the condition now designated by the latter term, the value of arsenic has been frequently shown since its recommendation by Haygarth, and the elder Bardsley in Manchester (Medical Reports, p. 32). I quite agree with the latter physician in his opinion that the remedy promises well in cases where the vital powers are diminished, and the ends of the bones, the periosteum, capsules, and ligaments are swollen; under the continued use of the drug I have known the joints return to their natural size. Sir R. Christison records a similar experience in cases of "nodosity of joints," and Dr. W. Begbie describes fully the case of a man with swellings of the small joints of hands and feet, very painful, especially at night and in changeable weather, and almost preventing any movement. The patient had received no benefit from a long trial of many remedies, but under a course of Fowler's solution recovered the use of the joints, and was able to resume his work. Dr. Fuller speaks highly of the remedy in "chronic rheumatism," and especially in rheumatic arthritis, when the skin is dry and inactive, and the patient chilly.