In these disorders, in which a profuse secretion is connected with local irritation, and with generally depressed nerve-power, Fowler's solution is often effectual, and it is especially so in patients subject to paroxysmal sneezing, with much itching about the alae nasi. Dr. Mackenzie had previously reported satisfactory cases of catarrh treated by doses of 3 min. and upward (London Medical Journal, July, 1851).