Though antimony is seldom now prescribed for this condition, the good results obtained from it, by Dr. Peddie especially, require some notice. He speaks of uniform success in upward of eighty cases, treated mainly by 1/2 to 1/4-gr. doses, given every two hours until improvement set in; emetic action was not marked, but occurred to some extent with the early doses: secretion from the kidneys and the skin was increased, but he attributed the benefit rather to a sedative effect on the nervous system and the lowering of vascular excitement (Edinburgh Monthly Journal, 1854). In America and in Germany, larger doses have been successfully used - Schroff, for instance, giving 4 to 6 gr. daily, and others the same dose every hour. The practice, however, is dangerous, because in this malady the circulation fails so readily, and Dr. Anstie has pointed out that antimonial treatment, though certainly successful in some cases, has ended unfortunately in others ("Reynolds' System," ii., p. 92). I have found its moderate use valuable in young robust men, especially in the first attack, and even when much gastric derangement was present: it is not so suitable for old or debauched subjects.