Doses of 5 to 15 gr. of the alkaline bromides are well borne by the stomach, but upward of 20 or 30 gr. will often cause irritation and nausea, with sense of weight and coldness, or later of warmth. At first the gastric secretions are rather lessened and appetite slightly increased, but after a time there is anorexia, and gastric catarrh and diarrhoea may occur, especially with the potassium salt. Bromide of sodium increases thirst as the chloride does. The sensibility and the reflex movements of the fauces and pharynx become much lessened under the full influence of the bromides, and even from their continued local application. If, however, these parts are inflamed, a strong solution may prove very painful.