Most of the secretions become more acid under the free use of this drug, and some of them, especially those of the skin and the bowel, are lessened in amount. Bobrick, however, found the quantity of urine and the amount of urinary sulphates increased by it. After large doses, Leyden and Munk distinguished different conditions corresponding to different alterations in the kidney; finding albumen alone, or with epithelial casts, or with fatty globules and epithelium, or in addition, hyaline casts, and blood- and pus-corpuscles.