In some few cases of nerve-debility and depression connected with overwork, anxiety, or excess, and exhibiting hypochondriacal symptoms - morbid fear, impaired mental capacity, and frequent rather deep-seated fixed headache - I have seen improvement under the use of nitrate, and have felt justified in connecting it with this drug, because iron, and bromides, and other remedies had been used without advantage, and the patient's mode of life and circumstances were not altered when the silver was commenced.

In hysterical or nervous headache it was valued by Dr. Graves, and others have found it useful in neuralgia, for which Paterson recommends especially the iodide. If the headache be accompanied with constipation or gastric disorder, an occasional laxative is required.