Luton applied the deep injection of this salt also to the treatment of these maladies.

In sciatica of chronic and obstinate character, 10 to 20 drops of the solution injected deeply near the seat of pain will lead to a localized suppuration which sometimes quite cures the original malady: it is best used in the nates at the point of emergence of the sciatic nerve.

In other chronic obstinate neuralgia, and, according to Le Dentu, in any deep-seated neuralgic pain of any part, similar treatment has proved of service: of a solution containing 1 part of nitrate in 5 of water he in jects deep into the cellular tissue 2 or 3 drops: this causes acute pain for the moment, and sometimes a small abscess afterward, but never serious trouble (Medical Record, 1877). Dureau, in a recent thesis (Paris, 1877), sums up very favorably the experience recorded up to the present time of this method of treatment; it is said to be both certain and rapid in its effects, and not to cause much irritation of the deep tissues. Luton himself used a 10 per cent., also a 5 per cent. solution, and others one of 25 per cent., injecting 5 min. - all with successful results.

In Chronic Joint-Disease, Synovitis, etc., equally good results have been recorded from the method of Luton - i.e., deep injections into the joint-cavity (Medical Record, November, December, 1877). The process may be compared with that of Thiersch for cancer, in which weak solutions only are used, and suppuration is not intended (v. p. 9).

Therapeutical Action (Internal)

The value of silver compounds is acknowledged in certain disorders of the gastro-intestinal mucous membrane, and of the central nervous system. In the former their action is a local one, doubtless of the same character as that exerted upon the external surface; in the latter they are given for a "constitutional" effect of tonic or indirectly sedative character, which may perhaps be resolved into a regulating or astringent effect upon the capillaries (Hudson, Lane). In support of this view has been quoted the power also possessed by these salts of moderating uterine and other discharges, but this is perhaps only contingent on the improved state of the stomach-functions; in the present state of our knowledge, however, the record of clinical facts is of more importance to us than the theories formed to explain them.