Laennec, Bricheteau, and other eminent physicians of a past generation, advocated the use of large and repeated doses in acute rheumatism, but later experience is against their adoption. I formerly used 1/4 gr. doses with advantage, especially when the temperature was not very high. Barbeau quotes cases illustrative of its value in acute rheumatism, when used as an evacuant previous to commencing quinine (Medico-Chirurgical Review, i., 1857, p. 266).