Rapid separation of fibrine in the heart-cavities seems to occur previous to death in many acute exhausting diseases, such as pneumonia, croup, peritonitis, etc., and after prolonged or difficult parturition. Dr. B. W. Richardson states that advantage may be derived in such apparently hopeless condition from the use of liquor ammoniae mx. every hour, alternately with iodide of potassium (Ranking, ii., 1872). Dr. Shepherd Fletcher (Manchester) has reported a well-marked case of embolism occurring in a puerperal woman and recovering under 5-gr. doses of ammonia carbonate given every hour (British Medical Journal, i., 1864), and Dr. Philipson has recorded another illustration of the same character (British Medical Journal, 1865). More recently, Dr. Richardson has written to point out distinctive signs of the separation of fibrinous coagula in the large thoracic vessels - e.g., dyspnoea with open air-passages, fulness of the neck-veins, feeble pulse with tumultuous heart-action, and weakened first sound: for such conditions he strongly advises the persistent administration of ammonia, not so much as a stimulant, but as a solvent of blood-clot, and preventive of putrefaction (Lancet, i., 1875). I cannot, however, yet adopt so sanguine a view of this medication (v. p. 254).