This section is from the book "Materia Medica And Therapeutics Inorganic Substances", by Charles D. F. Phillips. Also available from Amazon: Materia medica and therapeutics.
Varices, without pain or ulceration, should seldom be interfered with by external treatment; but I have frequently known a very marked improvement in them while patients were under a regular course of 15 to 30 min. of the perchloride of iron, three times a day, for other affections. To judge by the recorded results of iron injections in varix, a large amount of success has been obtained with much less risk than in the last-named diseases; but yet the method is not generally approved by most modern authorities. Minor reports five good cases in which either the scrotum or the legs were affected, and three or four drops of a solution of persulphate (1 part in 4 of water) were sufficient for cure; the patient was in the upright position, and pressure was carefully applied above and below the seat of puncture (Ranking, ii., 1860). Sentoux, collecting 126 cases, found 100 cured, 19 relieved, 6 unaffected, and only 1 death. Denuce reports many successful cases (Moniteur des Sciences Medicales, November 15, 1862; British and Foreign Review, April, 1862); the perchloride was used with certain precautions. Desgranges thought the method, with ordinary care, to be free from danger - 2 drops sufficed for the largest varicose lobule. He notes the improvement in varicose ulcers after the operation (Abstract: British and Foreign Review, ii., 1858). Morgan, of Dublin, succeeded in obliterating part of the saphena vein by injecting 5 drops of Monsel's solution in two places, carefully isolated: coagulum formed in fifteen minutes, and the case did well; in another, with irregular dilatation, and large varicose clusters about the knee, the same method of injection above and below was equally successful (Medical Press, July 14, 1869). Brainard's experiments on the formation of clot in veins under the use of sulphate were very satisfactory (loc. cit); and Gross, speaking of naevus, and discouraging the use of perchloride, yet says that by "Monsel's solution any case of arterial or venous tumor, unless very bulky, may generally be promptly and effectually cured" ("System of Surgery"); this would seem sufficient to warrant a further trial.