This section is from the book "Materia Medica And Therapeutics: An Introduction to the National Treatment of Disease", by John Mitchell Bruce. Also available from Amazon: The pharmacology and therapeutics of the materia medica.
A product of the distillation of Wood Tar.
Characters. - A liquid, colourless or with a yellowish tinge, a strong empyreumatic odour, and burning taste. Soluble, sparingly in water; freely in alcohol, ether, and glacial acetic acid. Sp. gr., 1.071. Coagulates albumen.
Impurity. - Carbolic acid; detected by becoming solidified by cooling.
Dose. - 1 to 3 drops, with mucilage or bread crumb.
Composition. - Creasote is not a simple body, but a variable compound of Guaiacol, C7H8O2, and Kreasol, C8H10O2.
Mistura Creasoti. Creasote, 16 min.; glaciai acetic acid, 16 min.: spirit of juniper, 30 min.; syrup, 1 fl.oz.; water, 15 fi.oz. Dose, 1 to 2 fl.oz.
2 Unguentum Creasoti. - 1 in 9.
Vapor Creasoti. 12 min. in 8 fl.oz. of boiling water.
The action of creasote is, practically speaking, the same as that of carbolic acid, to which the student is referred. Before the latter came into general use, creasote was not unfrequently employed for the same purposes internally to which carbolic acid is now put; but the uncertainty of its composition and strength, as a complex product, renders it inferior to phenol in this respect.
The Unguentum is employed in dry skin diseases. The Vapor is disinfectant and deodorant in phthisis, chronic bronchitis, gangrene, and other diseases of the lungs attended by foul discharges. A combination of creasote, iodine, and various volatile substances such as ether, chloroform, and spirit, has lately become popular as a constant inhalation in phthisis. The Mistura Creasoti is intended chiefly as a remedy in vomiting, especially when this is due to pyloric obstruction, dilatation of the stomach, and the development of fermentation; but it ba3 also been recommended in the vomiting of pregnancy, hysteria, and sea-sickness.
A specific and remote local effect has lately been claimed for creasote, when given by the stomach, namely, as a disinfectant and deodorant in phthisis with antipyretic and healing properties.
Iodoformum. Iodoform. CHI3. (Not Officinal)
Characters. - Small lemon-coloured lustrous crystals, with a powerful and persistent saffron-like odour, and an unpleasant sweetish taste. Insoluble in water; soluble freely in fixed and volatile oils and ether. It contains more than 90 per cent of iodine.
Dose. - 1/2 to 3 gr. or more.
Preparations. Unguentum Iodoformi (U.S.P.). - 1 to 9 of benzoated lard, lodoformum Praecipitatum. - An impalpable yellow powder. Iodoform Wool. - Absorbent Cotton Wool, containing 10 per cent of iodoform.
Iodoform is an antiseptic and disinfectant, but destroys organisms less readily than carbolic acid. It is a very powerful deodorant. Applied to the human tissues, it produces little or no irritation.
Iodoform is used to cleanse foul ulcers, especially of venereal origin; and may possibly have a special effect on strumous ulceration. It has also been extensively applied as an antiseptic dressing to healing wounds, the best forms being the wool and the ointment. Sometimes iodoform gauze has been employed. Iodoform bougies for insertion into the urethra and os uteri have not given satisfaction. A powder of iodoform diluted with quinine or bismuth is a valuable insufflation in ozcena and ulcers of the mouth and throat.
Iodoform is occasionally absorbed from wounds, causing sickness and fever, restlessness and delirium in some subjects, drowsiness and collapse in others. Iodine is possibly set free in the blood, appearing in the urine as iodide of sodium. Iodoform has been used in an endless variety of diseases internally, but unfortunately with no special benefit.