Exhaust pepper with stronger ether, remove the ether by distillation and evaporation, and separate the oleoresin from the piperine in the residue by expression through a muslin strainer.

Composition. - Piperine, resin, and volatile oil. Piperine is a crystalline principle, almost neutral, tasteless, inodorous, and insoluble in water, and is isomeric with morphine. The resin possesses the pungent taste of the drug, and gives the oil its aromatic smell.