This section is from the book "Materia Medica Pharmacy, Pharmacology And Therapeutics", by W. Hale White. Also available from Amazon: Materia Medica Pharmacy, Pharmacology And Therapeutics..
(Not official.) - C6H12N4=139.86. Synonym. - Hexa-methylentetramin.
It is obtained by the action of 4 molecules of Ammonia on 6 molecules of Formaldehyde: 4H3N+6Ch2o=C6H12N4+6H2O.
It occurs as colorless, transparent, six-sided rhomboids or prisms, of a sweetish, afterwards bitter taste, which are permanent when kept dry. It is odorless at ordinary temperatures, but heating evolves a peculiar fishy odor. Solubility. - Readily in 1.25 parts of water, in Chloroform, Alcohol, Acetone, and Carbon Bisulphide; insoluble in Ether.
All acids decompose it in the presence of warmth.
Dose, 7 to 15 gr.; .50 to 1.00 gm. in full tumbler of plain or carbonated water.
Large doses in man, e.g., 150 grains; 10 gm., are well borne; intravenous injections in rabbits and dogs do not increase, but, rather, slightly lower blood-pressure. Very large doses cause albuminuria in rabbits and haematuria in dogs. Of most importance is the inhibitory action of this remedy upon microorganisms when it is split up into formaldehyde and ammonia, the former being the active agent. This takes place for the most part, after ingestion, in the urine, which is not only of the proper temperature but also contains uric acid and acid salts which are efficient. Further, as Bardet showed, it will dissolve uric acid at the temperature of the body. Lastly, it may or may not produce diuresis.
This remedy is of especial value in diseases of the urinary passages. In ammoniacal fermentation of the urine, which is especially frequent in the cystitis of prostatic hypertrophy, the maximum dose given for two or three successive days is efficient in clearing that excretion. Inasmuch as the growth of the micro-organisms is inhibited, the remedy should be continued in sufficient amount to maintain this result. In gonorrhceal posterior urethritis, cystitis and pyelitis the results are equally favorable. It may be employed as a prophylactic measure before operations upon the genito-urinary tract. For the uric acid diathesis it has been used with good results by most, with failure by a very few, physicians. Since it is not always diuretic, other measures should be employed for this purpose. As a lithontriptic some success has been claimed. For phosphaturia excellent results are reported. Inasmuch as the bacillus of enteric fever is found in a very considerable percentage of urines from patients suffering from this disease, and failure to disinfect this excretion is a source of danger, urotropin should be administered not only for this purpose but as well to avoid the cystitis which sometimes supervenes in the course of the disease.