This section is from the book "Materia Medica And Therapeutics - Vegetable Kingdom", by Charles D. F. Phillips. Also available from Amazon: Materia Medica And Therapeutics: Vegetable Kingdom.
When glycerine is subjected to the action of nitric and sulphuric acids, a body known as nitro-glycerine or glonoine, discovered by Sobrero,1 is formed. Its composition is C3H5N3O9. It has an oily consistence, but is heavier than water (sp. gr., 1.60), in which it is insoluble. It is very soluble in alcohol.
Physiological Action. - Its physiological effects were first studied by Dr. C. Hering (homoeopath), of Philadelphia, in 1848, since which time it has been experimented with by many, who, without exception, confirm the more prominent phenomena described by him. Taken in doses of one-tenth grain, it produces rapid increase of pulse, with congestion of the head (internal and external), accompanied with severe bursting headache, and sometimes with nausea and vomiting. In doses of 1/100 grain it produces the same kind of phenomena, but less in degree, and in susceptible persons even much smaller quantities are capable of producing appreciable effects, as we know by personal experience. These effects, after moderate doses, pass off after a few hours. In many respects it greatly resembles the nitrite of amyl.
Therapeutic Action. - Dr. Murrell,2 of England, while working with nitro-glycerine, was struck with the resemblance referred to, and employed it with satisfaction in three cases of angina pectoris in doses of 1/100 minim. Drs. Hammond, Hamilton, and others of this city have used it for some time in epilepsy and other anaemic conditions of the brain. It is somewhat slower in its action than amyl nitrite, but its effects are more enduring.
Preparations And Dose. - None officinal. The most convenient form for its administration is a one per cent. solution in alcohol - dose, mj. ±.)