A. Bluish-gray color to the skin after long continued use, 1,1, 210; 6,302; 18, 45; 529, 356, and many others.

Purplish-slate color, Purdon, 135, 2: 44.

Dusky lead color, 210.

Steel-gray color, most marked on the face, more marked on flexor than extensor surface of limbs. The silver deposit was easily distinguished in thin sections under the microscope. Patient had taken about 3 1/2 ounces of Argenti nitras. Frommann, 112, '59, 17; 135.

Grayish-black color on the face, later grayish-blue, most deeply marked on the face. On microscopical examination of the skin after death the deposit of silver was easily distinguished. The patient had taken 5,672 pills, containing an aggregate of 34 grammes of nitrate of silver. Riemer, 108, '75, 298.

When taken into the stomach, it is, after conversion into chloride of silver, as some maintain, carried by the blood-vessels to the skin, where, by exposure to light, it gives to the integument a violet hue. Others suppose that it is absorbed as nitrate of silver, and is converted into a chloride in the rete mucosum, while still others believe the chloride to be reduced by the action of light and metallic silver deposited, 10, 1: 363.

Pruritus, erythema, papules, Charcot, 89, 75.

B. When moistened and lightly applied to the skin the track of its passing soon becomes violet-brown, and at last black. When more prolonged application is made, a small slough may ensue, 16,3: 74.

D. Abortion of variolous pustules, 16, 3: 85.

Pruritus pudendi, 5, 180; and others.

Vascular and exuberant granulations, 3, 1: 359, and others.

Erythema nodosum, psoriasis, Chapman, 138, Oct. 14, '37.

Psoriasis (Hebra), Sycosis (Warion), 17, 967.

Burns, Skey, 137, Aug. 27, '70, (H.G.P.)

Eczema, Piffard, 143, Oct. 26, '78.

Eczema ani, 202.

Pemphigus, zoster, Duchesne-Duparc, 113, '46, 84 et seq.

Chromophytosis, 208.

Furuncle (ibid.); Piffard, 88, 144.

Erysipelas, Duchesne-Duparc, 113, loc. cit.

In erysipelas: "The affected part should be well washed with soap and water, then with water alone, to remove every particle of the soap, then to be wiped dry with a soft towel. The concentrated solution, of four scruples of the nitrate of silver to four drachms of distilled water is then to be applied two or three times on the in-flamed surface, and beyond it on the healthy skin to the extent of two or three inches. The solution may be applied with a small piece of clean linen, attached to the end of a stick, the linen to be renewed at every subsequent application. As the solution of the nitrate of silver is colorless, it is necessary to pass a little linen just moistened over every part where it has been used, in order to be equally diffused, so that no part may be left untouched. In about twelve hours it will be seen whether the solution has been well applied. If any inflamed part be unaffected, the solution must be immediately reapplied. Sometimes, even after the most decided application of the nitrate of silver, the inflammation may spread; but it is generally much less severe, and is eventually checked by repeated applications. It is desirable to visit the patient every twelve hours, until the inflammation is subdued." Higginbottom, 162, Jan. '69, 34.

In superficial inflammations other than erysipelatous, nitrate of silver may often be used to great advantage, 18, 49.

Lupus vulgaris, 97, 2: 367, | H.G.P.)

Remarks

Internally, nitrite of silver is not used in dermatology, so far as I am aware. It ii possible, however, that it might prove useful in some of the pruriginous or other affections depending on pre-existing nerve lesion.

Externally, it has manifold uses, among which are the repression of exuberant granulations, and the stimulation of sluggish erosions and ulcerations. The relief which a 2 per cent. to 3 per cent. solution affords, when applied to recent burns of the first or second degree, first pointed out, I believe, by Mr. Skey, I have frequently verified. The action of nitrate of silver as a caustic, either in saturated solution or in the solid form, is exceedingly mild.and superficial, and cannot be depended on when anything more than surface action is desired. A very common but improper application of it is to recent venereal sores. In chancres it is uncalled for, and does more harm than good; in chancroids it is inefficient. It is also sometimes applied to the surface of lupoid and other malignant or semi-inalignant ulcerations. Here again it is usually inefficient, and not unfre-quently stimulates the disease to increased development. There is, however, an effective method of employing it in lupus, which will be considered in connection with that disease.