It was found that they principally implicated the superficial layer of the cutis vera. The papillary layer at the affected part was flattened out, stretched, and even excavated, and contained a large number of small cells, and a quantity of newly formed fibrous tissue (fibro-nuclear layer).

Blood-vessels were seen to be numerous in all the specimens, both in the neighborhood of the sweat-glands and also in other parts of the cutis vera; immediately beneath the pustule they were devoid of blood. The vessels passing into the depth of the corium in the centre of the pustule, and also those of the periphery, were seen to be ensheathed in streaks of exudation corpuscles. No evidence of the rupture of any blood-vessel was to be obtained.

The sweat-glands seemed entirely unaffected, even in close proximity to the pustules, although in several places the blood-vessels were found affected as before mentioned. In one or two sections the ducts were seen opening upon the surface of the skin, close to the affected part.

No evidence was afforded of the implication of any hair-follicles.

In both pustules examined there was a distinct separation of the inflamed tissue from the subjacent healthy structures.

The epithelium bounding the pustules was found to be in a perfectly healthy condition.

From the above, it is inferred that the pustules are not of the nature of acne, but are due to a superficial localized dermatitis, resulting in cicatricial tissue. In the present case, however, no evident cause of such localization (as, for example, rupture of blood-vessels) could be demonstrated, Duckworth and Harris, 195, '79, 476.

C. Eczema, 73, 75.

Psoriasis (Belcher, Arnould, Roux de Brignolle), 17, 561; 81, 22. Lupus, Gay, 137, 2/71, 814; 76, 474; 117, 85: 41.

Syphilis.

D. Lupus, 77, 320.

Scabies, Spencer, 162, '69, 196. Leprosy, 58, 376; (H.G.P.).