To what has been already said concerning this drug, I can add but little. Given in small but gradually increasing doses for a considerable period, or in larger doses for a shorter time, it will probably, in the majority of instances, remove the eruption, provided the patient can take it long enough. + It sometimes, though rarely, aggravates the trouble. If it be used at all, its employment should be thorough, and if a quick cure is desired, the object should be to introduce into the system the greatest possible amount of the drug in the shortest space of time that is consistent with due safeguards against the production of too much reactive irritation. It is of course difficult to determine in advance the appropriate dose for any given case; hence it is best to commence with small doses, increased from day to day until conjunctival or gastric irritation, etc., warn the physician that the limit of "tolerance" has been reached. The dose must then be graduated so as to keep just within this limit until the removal of the lesions is effected.