A. Excreted in part by the skin, 9, 1120.

Bromine has been chemically detected in the pustules produced by bromide of potassium, Guttmann, 112, 74. 541.

In large doses (300 grains a day), sensibility of the skin so much diminished that sticking, burning, and pinching are not perceived, 6, 40.

Urticaria, 72, 154.

Prurigo, Purdon, 135, Oct. '67; Astesiano (La Liguria Medica, '71), 131, 6: 63.

Coppery papules on forehead, Hameau (Jour. de med. de Bord., mar. '68), 128, '68, 269.

Acne on the face, forehead, and shoulders, 4, 366.

Eruption like varicella, but the vesicles, instead of drying up, become in many places confluent, and the clusters thus formed showed a tendency to enlarge and exhibited numerous points of suppuration. Cholmeley, 116, 2/69, 633.

Macules, papules, erythema, pustules, Duhring, 145, Nov. 30, '78. An eruption, generally acneform, occurring chiefly on the face and back, but it may affect even a larger surface. These spots do not generally suppurate nor leave scars. The acneform spots may become true boils, and these boils sometimes form large ulcers with conical scabs like rupia, 5, 95.

There are five principal forms of eruption. The first of these is acneform. It appears shortly after the commencement of treatment (of epilepsy) when the doses of the drug are three or four grammes. The eruption commences by pustules. It appears by preference about the shoulders, forehead, and nose. First of all little pin-head pustules appear, each surrounded by a red areola. Later the pustule enlarges and acquires a hard, indurated base. In this condition it may persist for weeks. Afterwards the pus is discharged, but a small reddish nodule remains for a long time. The pustules vary in number, and are most plentiful when the dose is suddenly augmented. The second form of eruption appears on the lower extremities, rarely elsewhere. It consists of rounded or elongated elevations, 2 cm. - 5 cm. In diameter, of rosy color, sometimes yellowish, as if due to pus beneath the epidermis. The surface is roughened by minute agminated pustules. In the rounded patches the centre is depressed. It is rare for the same patient to have more than two or three of these at a time. The elevations are painful and sensitive to the touch except the depressed centre, which is anaesthetic. Later a creamy fluid is discharged, which forms a thick crust. They sometimes ulcerate, and may coexist with the form first described.

* Du bichromate de potasse comme antisyphilitique. These, Paris, 1866.

The third form resembles erythema nodosa, and affects the skin of the upper and lower extremities and trunk, but spares the face. The appearance of the eruption is preceded by pruritus and pain in the affected limbs, which may become edematous.

The fourth form is furuncular and the fifth eczematous in character, Voisin, 178, '68, 603.

Pustules on chin, cheeks, and forearms in a nursing child whose mother was taking bromide (Jour. de l'Acad. de Med. de Turin), 163, Sept. 10, 76.

In a child, after taking two hundred and fifty grains, an eruption appeared. On microscopical examination it was found that the sebaceous follicles were chiefly affected, exhibiting marked evidences of epithelial hyperplasia, Neumann, 177, '73, No. 49.

Erythema, vesicles, scales, 205.

The eruption had somewhat the appearance of a half-ripe raspberry. It was raised about one line or so above the level of the surrounding skin; the margins were abruptly defined and the adjoining skin perfectly healthy. It seemed to consist of hypertrophied papillae, covered over with a thickened, reddened epidermis. It was not tender to the touch. There was hardly any appreciable exudation from the surface. It much resembled a mucous tubercle, except that its surface was dry, Parker, 172, 12: '79, 200.

D. Eczema, Piffard, 143, Oct. 26, '79.