This section is from the book "A Treatise On Therapeutics, And Pharmacology Or Materia Medica Vol1", by George B. Wood. Also available from Amazon: Part 1 and Part 2.
The dose of the powdered leaves is two or three grains, twice or thrice daily. That of the powdered seeds is one grain, repeated as often. Should this dose produce no effect in a day or two, it should be gradually increased until it gives rise to some evidence of its action, as dimness of vision, dryness and stricture of the throat, etc. Fifteen or twenty grains of the leaves have often been given without unpleasant effects. The medicine, however, is more frequently administered in extract. The U. S. Pharmacopoeia directs two extracts, one of which is the inspissated juice of the leaves, and the other is prepared by evaporating a tincture of the seeds.
The Extract of the Leaves (Extractum Stramonii, U. S) is made by expressing the juice of the leaves, heating to coagulate the albumen, then filtering, and evaporating. The preparation is of unequal strength. The commencing dose is one grain, to be repeated and increased in the same manner as the powder.
An Alcoholic Extract (Extractum Stramonii ALcoHolicum, U. S.) is prepared from the leaves, by the U. S. Pharmacopoeia, by first forming a tincture by percolation, and then evaporating. The dose is a grain.
Extractum Stramonii, Br.) is prepared by evaporating a tincture of the seeds. It is a stronger and more equable preparation than the preceding, and may be given in the dose of one-quarter or one-half a grain, to be repeated and increased in the same manner.
The Tincture of Stramonium (Tinctura Stramonii, U. S., Br.) is made from four ounces of the seeds and two pints of diluted alcohol. It is an excellent preparation, and may be administered in the commencing dose of ten minims or twenty drops.
The Ointment (Unguentum Stramonii, U. S.) is prepared by simply mixing a drachm of the extract with an ounce of lard; the extract having been first rubbed with half a fluidrachm of water. It may be used for frictions over painful surfaces, as an application to hemorrhoidal tumours, and as a dressing to irritable ulcers.
Daturia, the alkaloid of stramonium, upon which its virtues probably depend, has been used in a few instances for obtaining the effects of the medicine; but its action is so precisely that of atropia that sufficient inducement is not offered for its preparation, and it is comparatively little employed.