Jackson says "that in the early stages of inanition" in young guinea pigs "the pancreas (like the other viscera) appears in general more resistant to loss in weight" and that "the pancreatic losses in the early stages of inanition" are "relatively slight," while in "advanced stages" of inanition the "pancreatic atrophy is extreme, being as a rule relatively greater than that of the entire body." He also says: "upon feeding after inanition, the pancreas recuperates rapidly and is soon restored to normal size and structure."

In humans the pancreas becomes small and firm during inanition. Cases are reported in which the pancreas appeared normal after death by starvation. Other cases are reported with considerable pancreatic destruction. Probably there were other causes than starvation at work in these latter cases.