Insanity. All modern investigators acknowledge the importance of autogenous poisons in the etiology of insanity. Hamilton (53) has made a special study of the urine and digestion in the insane and offers the following important conclusions: -

1. Varying and fugaceous illusions and hallucinations, pallor, increasing exhaustion, verbigeration, confusion and unsystematized delirium are due to autointoxication.

2. Paranoia, chronic stuporous conditions and some forms of dementia have little to do with auto-intoxication.

3. Auto-intoxication is most common in post-febrile states, traumatisms, alcoholism and drug disorders.

4. The variation in the excretion of combined urinary sulphates, keeps pace with the changes in an established insanity. Epileptiform attacks are directly connected with putrefactive conditions in the intestine.