It will be the general plan of this paper to discuss the individual factors of auto-intoxication, their properties and the conditions under which they may be formed, and the diseases into whose etiology they enter, or which they may complicate.

Believing that recent advances in experimental medicine are of more importance, the more commonly known features of auto-intoxication will be but briefly discussed.

It would be interesting to make deductions and conclusions as to the rational treatment of diseases, caused by auto-intoxication, but this is not properly within the scope of this paper which deals exclusively with the condition as an etiological factor, and treatment will be referred to only as argument for the validity of theoretical views.

It would also be interesting to discuss the poisons of the specific infectious diseases, but the writer will adhere to the view that they are not auto-genetic, but the result of definite extraneous infection.