As an external cooling and astringent lotion, lead, in the form of diacetate, or Goulard's extract, has long been recognized as a useful remedy by veterinarians. It is applied to ulcers, cracked heels, mallenders and sallanders, and in olive or linseed oil it makes an efficacious lotion for that eruption commonly known as "mud fever". It enters into several lotions and ointments for the treatment of grease. With glycerine it forms a glycerole of lead, and is applied in poultices and upon painful surfaces. Goulard lotion diluted with distilled water is a favourite application in the treatment of inflamed eyes.

Internally administered lead is powerfully astringent, affecting the mucous membrane lining the stomach and bowels. In cases of dysentery it has a soothing and healing effect upon the abraded surfaces of the bowel, and is given in conjunction with opium to arrest haemorrhage in distant organs, as the lungs, kidneys, and womb.

It is readily taken up by all the tissues, and lead-poisoning is not uncommon among animals in the neighbourhood of lead-mines. (See Poisoning.)