These lack both the internal order and the definite forms which characterize organized new growths, and their development comes under the dominion of chemical laws. Between the rudiments of what is, and what is not organized, there is no distinction in point of form. In a chemical sense non-organized growths are composed both of unorganized and of organized substances, either singly or conjointly, and it is even common enough for a new growth to be made up through the mechanical blending or interlacing of organized with unorganized materials. All these considerations taken together preclude any marked discrimination between the two.

There are, upon the one side, undoubtedly new growths representing perfect unorganized formations, for example, certain concrements. On the other side, however, non-organized new growths originate under conditions and forms which have induced us, notwithstanding their unorganized nature, to discuss them along with the organized new growths. We may instance the forth issuing of lime-salts - as cretefaction, ossification, incrustation; of the free fats; of colloid; of tubercle.

The material for non-organized new growths in general, is contained both in the textures, and in fluid and solid blastemata; the material for a special order of non-organized new growths, in the proper fluids of secretion. Its nature varies considerably. It consists of protein substances, certain gluten-substances, horn-substance, fats, pigments, acids, salts. In a more extended sense, even the various gases and fluids occurring in textures, or in the cavities of the body or of organs, the fluid of genuine dropsy for instance, belong to the class.

Without for the present taking these last into the account, we have to observe with reference to unorganized new growths:

The elementary forms are the amorphous, the glebous, the laminate, the granular (down to the finest molecule or point-mass), the crystalline. Certain substances possess a determinate form, dependent, however, for the most part, upon their peculiarity of composition, upon the conditions under which they become severed from their primitive combinations, and upon their mode of development. Thus protein substances occur, both structureless, and in a glebous or a molecular form.

These materials constitute secondary formations, either alone or with the intervention of a bond-medium, for example, mucus. This is often furnished, together with the external moulding or form of the new growth, by the glutinous basis of a texture; for example, in the so-termed ossification of a fibrous tumor. Both in form and size they manifest great variety, not readily susceptible, however, of generalization. We allude more particularly to calculous concretions! In consistency they are in various degrees soft or firm.

Above all, their chemical composition varies greatly. As regards concretions and calculi, these readily divide into two groups, namely, into such as form out of fluids of secretion, and consist of the respective components of those fluids, and into such as become developed out of blaste-mata and textures. These last have a composition corresponding with their base, and very commonly consisting of phosphate and carbonate of lime, and of magnesia.

Respecting the origin - the mode of production - of non-organized new growths, it may be stated generally -

1. They are exudates or secretions in a primitive form of non-organization, as exemplified in crude fibrin, and encysted colloid and fats.

2. They are the result of various transformations of such products. To this order belong :

(a.) Formations arising out of the conversion of exuded and secreted protein materials into glutinous, into horny substance, into fat; for example, the conversion of fibrin and albumen to colloid, to horny substance, to fat in the molecular or crystalline form.

(6.) Formations arising out of a process imitating ossification in fluid or solidified, unorganized or textural bases; a liberation of lime-salts (phosphate and carbonate) out of their primitive combinations, as crete-faction, ossification, lime-incrustation, concretion. (See "Bone Formation.")

(c.) Formations brought about by a more palpable deposition of all, or only of certain, components of a fluid in which they are held in solution or suspension. They are most especially prone to form in secreted fluids, and either consist purely of specific ingredients proper to them, or occur blended with other elements. They constitute calculous concretions. The cause of their separation is manifold. It may be that the fluid has become more concentrated, for example, by loss of water, their solvent medium, through exosmosis (resorption) or more especially by evaporation. Again, we may mention, besides the precipitation from fluids of certain specific components, the inspissation and exsiccation of secreted and exuded fluids in their totality; for instance, of mucus, of ear-wax, of the smegma praeputii, of the bile, of exudate, of pus, etc. Or else it is a consequence of a chemical conversion of the fluid, - of the solvent, or of the dissolved substance. For instance, the free acid of normal urine retains the phosphatic earths in solution; when, however, the urine is rendered alkaline, be it by the presence of mucus or exudate, or by conversion of the urea into carbonate of ammonia, the phosphatic earths become precipitated. If the lithates present in the urine become decomposed by an excess of acid in the urine, the lithic acid, as the less soluble, is thrown down. The soluble phosphate of magnesia present in almost all the fluids becomes precipitated, the moment that it enters into a combination with ammonia, to ammonio-phosphate of magnesia.

Unorganized new growths possess sometimes a local, sometimes a general import. Thus, urinary calculi may be the result either of mere local contingencies, or of various anomalies of general nutrition, that is, of a dyscrasial process.