In this form the new-formation of epithelial cells is not very rapid or vigorous, and it is accompanied by an excessive formation of connective tissue in the form of stroma. » Originating in the glandular epithelium, long processes composed of rows of cells, often with few abreast, are produced. These processes seem to be peculiarly irritating, as they give rise to the production of round cells and of dense connective tissue, which are sometimes more manifest than the proper epithelial elements. These elements may, in fact, degenerate, and leave little besides condensed hard connective tissue.

Cancer of stomach in the form of a circular ulcer with infiltrated walls.

Fig. 393. - Cancer of stomach in the form of a circular ulcer with infiltrated walls.

The cancer mostly begins in the pyloric region, but extends inwards till, in some cases, it has involved the entire wall of the stomach, except the fundus. The wall of the stomach is converted into a stiff hard mass, which may be, in some places, an inch in thickness. The surface of the affected portion of the stomach is irregular, with rounded prominences, and there are sometimes ulcers present, but there is not general ulceration as in the case of the epithelial and medullary forms. The affected portion of the stomach is often greatly contracted in this disease, especially the pyloric region.