Of these the most important are the Cancers. We sometimes meet with primary cancer in the gall-bladder resembling in structure cancer of the stomach and intestine. By extension it may largely involve the liver tissue. In the great majority of cases gall-stones are present in the gall-bladder in cases of primary* cancer, and the irritation of the calculi is to be regarded as the cause of the cancer. We have already seen that some of the cancers of the liver probably take origin in the finer bile ducts in its substance.

Literature

Gall-stones - Schuppel, Ziemssen's Handb., viii.; Renneke, Deutsch. Arch. f. klin. Med., 1876; Nadnyn, Verh. d. X. Congr. f. inn. Med., 1891; Janowsky, Ziegler's Beitrage, x., 1891. Congenital atresia of ducts - Thomson (with literature), On congen. oblit. of bile-ducts, 1892. Cancer - Sigoert, Virch. Arch., cxxxii.. 353, 1893; Zenker, Prim. Krebs der Gallenblase, Leipzig, 1889.