Glycogenic Infiltration is a deposit of glycogen within the cells. It is found normally in small amount throughout the body except in the mammary glands and central nervous system.

It is greatest in amount in the cells of the liver, in voluntary muscles, and in the kidneys; is also present normally in the blood, both in the plasma and in the cells, particularly the polymorphonuclear leukocytes. It is also commonly found in malignant tumors of mesodermic origin (sarcomata).

The origin of the glycogen is not clear; it is a carbohydrate, but seems to be derived from protein and carbohydrate substances. Glycogen is most frequently found in the condition known as diabetes.

Tissues containing large amounts of glycogen may have a distinct hyaline appearance. The reactions, however, differ, as it is soluble in water, but not in alcohol, ether, or xylol; is colored a brownish red on the addition of tincture of iodin I part, absolute alcohol 4 parts. The brown is not changed to blue on the addition of sulphuric acid.

Microscopically, glycogen occurs in the cells in clear, colorless droplets, usually near the nuclei.