Spindle-Cell Sarcoma is one that is made up of spindle cells, either large or small. Is one of the commonest forms.

These tumors are quite firm, white, and very little juice can be scraped from the cut surface. The cells are arranged in irregular bundles and have oval vesicular nuclei. The amount of intercellular tissue may be very great, making the tumor quite hard; is then known as a fibrosarcoma and is but slightly malignant. It is often difficult to determine whether the tumor is a sarcoma or a fibroma.

The spindle-cell sarcomata are relatively benign; they frequently do not give metastasis, although recurring after removal.