The Peyer's Patches are pigmented and bile may be found in the intestinal contents. The lesions are most marked in the lower portion of the small intestine, in which respect cholera differs from dysentery and poisoning by the metallic salts, which involve the large intestine.

In some cases there may be a hemorrhagic gastritis or an ulcerative colitis.

In a person dying from cholera there will be hyperemia of the pia, hyperemia and parenchymatous degeneration of the kidney, and bronchopneumonia. The liver and spleen will be smaller than usual.

Early in the course of the disease the bacillus is present in the intestinal contents in great number, in a pure culture.