146. see Kit, S.: The Role of the Hexose Monophosphate Shunt in Tumors and Lymphatic Tissues. Cancer Res., 16: 70, 1956.

147. Knox, W. E.: Two Mechanisms which increase in vivo Liver Tryptophan Peroxidase Activity: Specific Enzyme Adaptation and Stimulation of Pituitary-Adrenal System. Brit. J. Exper. Path., 32: 462, 1951.

148. Knox, W. E., Auerbach, V. H. and Lin, E. C. C: Enzymatic and Metabolic Adaptations in Animals. Physiol. Revs., 36: 164, 1956.

149. Knox, W. E. and Mehler, A. H.: The Adaptive Increase of the Tryptophan Peroxidase-Oxidase System of Liver. Science, 113: 237, 1951.

150. Kosaki, T., Ikoda, T., Kotani, Y., Nakagawa, S. and Saka, T.: A New Phospholipid Malignolipin in Human Malignant Tumors. Science, 127: 1176, 1958.

151. Lajtha, L. G.: Bone Marrow Cell Metabolism. Physiol. Revs., 37: 50, 1957.

152. de Lamirande, G.: Biological and Biochemical Effect of Deoxyribonuclease on Mice bearing Ehrlich Ascites Carcinoma. Proc. Amer. Ass. Cancer Res., 3 (2): 105, 1960.

153. de Lamirande, G. and Allard, C: Studies on the Distribution of Intracellular Ribonucleases. Ann. New York Acad. Sci., 81: 570, 1959.

154. de Lamirande, G., Allard, C. and Cantero, A.: Intracellular Distribution of Desoxyribonucleo-depolymerase in Normal Rat Liver, Liver Tumor, and Liver of Animals fed p-Dimethylaminoazobenzene. Can. J. Biochem. Physiol., 32: 35,1954.

155. de Lamirande, G., Allard, C. and Cantero, A.: Cystine-Cysteine Concentration in Homogenate and Cell Fractions of Rat Liver during Azo Dye Feeding and Regeneration and in Rat Liver Tumor. Rev. Can. Biol., 14: 184, 1955.

156. de Lamirande, G., Allard, C. and Cantero, A.: Purine Metabolizing Enzymes in Normal Rat Liver and Novikoff Hepatoma. Cancer Res., 18: 952,1958.

157. see Langenbeck, W.: Die organischen Katalysatoren und ihre Beziehungen zu den Fermenten. Berlin, Springer Verlag, 1949; see also The Chemism of Organic Catalysts and Enzyme Actions. Forschungen und Fortschritte, 26: 307, 1950.

158. Le Clerc, J.: Action of Ribonuclease on the Multiplication of the Influenza Virus. Nature, 177: 578, 1956.

159. Ledoux, L.: Action of Ribonuclease on Certain Ascites Tumours. Nature, 175: 258, 1955.

160. Ledoux, L.: Action of Ribonuclease on Two Solid Tumours in vivo. Nature, 176: 36, 1955.

161. Ledoux, L. and Baltus, E.: The Effect of Ribonuclease on the Cells of the Ehrlich Carcinoma. Exper., 10: 500, 1954.

162. Ledoux, L. and Brachet, J.: Remarks on Preparations of Ribonuclease from different Manufacturing Sources. Biochim. Biophys. Acta, 16: 290, 1955.

163. Ledoux, L., Brandli, S. and Paepe, J. C. De.: Ribonuclease Activity and Ribonucleic Acid Content of Homologous Human Normal and Cancer Cells. Nature, 181: 913, 1958.

164. Ledoux, L., Le Clerc, J. and Brachet, J.: Action of Ribonuclease on the Embryonic Development of Batrachians. I. Experience with Microinjection. Exptl. Cell Res., 9: 338, 1955.

165. Ledoux, L., Le Clerc, J. and Vanderhaeghe, F.: Influence of Ribonuclease on the Division of Amphibian Eggs. Nature, 174 : 793, 1954.

166. Ledoux, L. and Pileri, A.: Action of Ribonuclease on Rat Bone Marrow and Mouse Ascites Tumour Cells. Biochem. J., 66: 25P, 1957.

167. Ledoux, L., Pileri, A., Poznanska, H. and Vanderhaeghe, F.: £tude du Metabolisme de l'Acide Ribonucleique au Cours de la Crois-sance du Carcinome de Landschutz (Ascite). Arch. Int. Physiol. Biochim., 66: 437, 1958.

168. Ledoux, L., Pileri, A. and Vanderhaeghe, F.: Activity de la Ribonuclease et Teneur en Acide Ribonucleique des Tissus Normaux et des Neoplasmes. Arch. Int. Physiol. Biochim., 66: 122, 124, 1958.

169. Ledoux, L. and Vanderhaeghe, F.: Action de la Ribonuclease sur la Croissance Neoplastique. V. Aspects Metaboliques de l'Effet Can-cerostatique. Biochim, Biophys. Acta, 24 : 340, 1957.

170. see Lehninger, A. L., Wadkins, C. L., Cooper, C, Devlin, T. M. and Gamble J. L.: Oxidative Phosphorylation. Experiments with Fragments of Mitochondria offer new Information about Respiratory Energy Conversion. Science, 128: 450, 1958.

171. LePage, G. A. and Sartorelli, A. C.: Purine Synthesis in Ascites Tumor Cells. Texas Repts. Biol, and Med., 15: 169, 1957.

172. Levvy, G. A.: The Preparation and Properties of β-Glucuronidase 4. Inhibition by Sugar Acids and their Lactones. Biochem. J., 52: 464, 1952.

173- Lewin, I., Lewin, R. and Bray, R. C: Xanthine Oxidase Activity during Mammary Carcinogenesis in Mice. Nature 180: 763, 1957.

174. Maddock, C: Private Communication.

175. see Magasanik, B., Neidhardt, F. C. and Levin, A. P.: Metabolic Regulation of Enzyme Biosynthesis in Bacteria. Physiological Adaptation. Am. Physiol. Soc, Washington, 1958, p. 159; also Magasanik, B.: The Metabolic Regulation of Purine Interconversions and of His-tidine Biosynthesis. A Symposium on The Chemical Basis of Development. Baltimore, The Johns Hopkins Press, 1958, p. 485. Ed. McElroy, W. D. and Glass, B.; and Magasanik, B., Magasanik, A. K. and Neidhardt, F. C: Regulation of Growth and Composition of the Bacterial Cell. Ciba Foundation Symposium on Cell Metabolism. London, J. and A. Churchill, Ltd., 1959, p. 334.

176. see Mayneord, W. V. et at.: Brit. Emp. Cancer Camp. Ann. Rep., 36, Pt. II: 90, 1958.

177. Mazia.: "SH and Growth". In Glutathione: Proceedings of Symposium held at Ridgefield, Connecticut, November 1953. New York, Academic Press Inc., 1954, p. 209. Ed. Colowick, S., Lazarow, A. and others.

178. Mazia, D.: Mitotic Apparatus. Symposia Soc. Exptl. Biol. No. 9. Fibrous Proteins and their Biological Significance. 1954, p. 335. (Publ. 1955).

179. Mendel, B., Myers, D. K., Uyldert, I. E., Ruys, A. C. and de Bruyn, W. M.: Aliesterase Inhibitors and Growth. Brit. J. Pharmacol., 8: 217. 1953.

180. Metzler, D. E. and Snell, E. E.: Deamination of Serine. I. Catalytic Deamination of Serine and Cysteine by Pyridoxal and Metal Salts. J. Biol. Chem., 198: 353, 1952.

181. Miller, J. A. and Miller, E. C: The Carcinogenic Aminoazo Dyes. Adv. Cancer Res., 1: 339, 1953. New York, Academic Press Inc.

182. Monod, J. and Cohn, M.: La Biosynthese Induite des Enzymes (Adaptation Enzymatique). Adv. in Enzymology, 13: 67, 1952. New York, Interscience Publ. Inc. Ed. Nord, F. F.

183. Montgomery, J. A.: The Relation of Anti-Cancer Activity to Chemical Structure. A Review. Cancer Res., 19: 447, 1959.

184. Moore, E. C. and LePage, G. A.: The Metabolism of 6-Thioguanine in Normal and Neoplastic Tissues. Cancer Res., 18: 1075, 1958.

185. Morell, D. B.: Xanthine Dehydrogenase of Chicken Liver. Biochim. Biophys. Acta, 18: 221, 1955.

186. Morton, R. K.: Enzymic Synthesis of Coenzyme I in Relation to Chemical Control of Cell Growth. Nature, 181: 540, 1958.

187. Mueller, G. C, Herranen, A. M. and Jervell, K. F.: Studies on the Mechanism of Action of Estrogens. Recent Progress in Hormone Research. New York, Academic Press Inc. 1958, vol. 14, 95. Ed. Pincus, G.

188. Narurkar, M. V., Kumta, U. S. and Sahasrabudhe, M. B.: Pyridine Nucleotide Synthesis in Host Tissues of Tumour-Bearing Animals. Brit. J. Cancer, 11: 482, 1957.

189. Nirenberg, M. W.: An Enzymic Defect in Ascites-tumor Cells. Biochim. Biophys. Acta, 30: 203, 1958.

190. Olson, R. E.: Oxidation of C"-labeled Carbohydrate Intermediates in Tumor and Normal Tissue. Cancer Res., 11: 571, 1951.

191. Olson, K. B., Heggen, G., Edwards, C. F. and Gorham, L. W.: Trace Element Content of Cancerous and Noncancerous Human Liver Tissue. Science, 119: 772,1954.

192. see e. g. Paus, W.: Inhalationsbehandlung der chronischen Bronchitis mit Trypsinferment. Med. Klinik, 53: 1955, 1958; Storm, O. and Nielsen, M. H.: Erfaringer med trypure novo aerosol ved behandling af nekrotiske sar. Nord. Med., 60: 1831, 1958; Varidase buccal (Led-erle). Schwz. Apoth.-Ztg., 96: 928, 1958; Giliar, E.: Zur Ferment-therapie bei Verdauungsstorungen. Med. Klinik, 54: 140, 1959: a. o.

193. Peters, R. A.: Lethal Synthesis (Croonian Lecture). Proc. Roy. Soc, B, 139: 143, 1951-52.