Chemistry Of Enzymes In Cancer | by Franz Bergel
The perpose of this book is to advance our newer knowledge of chemical medicine in the cause of clinical practice. The interdependence of chemistry and medicine is so great that physicians are turning to chemistry, and chemists to medicine in order to understand the underlying basis of life processes in health and disease.
| Title | Chemistry Of Enzymes In Cancer |
| Author | Franz Bergel |
| Publisher | Literary Licensing, LLC |
| Year | 1961 |
| Copyright | 1961, Literary Licensing, LLC |
| Amazon | Chemistry Of Enzymes In Cancer |
Foreword- Our Living Chemistry Series was conceived by Editor and Publisher to advance our newer knowledge of chemical medicine in the cause of clinical practice. The interdependence of chemistry and medicine i...
- Introduction
- Then they assayed to look but, .... they could not look steadily through the glass; yet they thought they saw something like the gate, and also some of the glory. . . . Bun van. Pilgrim's Progress ...
- The Search For Chemical Differences
- The worker in the field of cancer research, apart from absorbing and extending fundamental findings from all investigations on biological problems, has been driven for quite a while to find difference...
- Part I. The Case For Enzymes
- It is even necessary to make a choice between the above groups of cellular constituents and to restrict a monograph such as this to one group, although it is obvious that all groups are inter connecte...
- 1. The Warburg Hypothesis
- O. Warburg,249 starting from the observation that a number of tumors possessed a high rate of glycolysis (see Figs. 1 and 14; see also Baldwin,22 and Dixon and Webb 88), meaning an unusual ability to ...
- 2. The Greenstein Hypothesis
- The second principal postulate is that of Greenstein.111 On the basis of numerous estimations of enzyme activity levels in normal and tumor tissues, mainly originating from his own laboratory, he came...
- 3. The Deletion Hypothesis
- This brings this journey (or should it be called climb) across the top concepts to the third principal hypothesis of cancer metabolism which is well supported by a considerable number of experimental ...
- Enzymes And Co-Factors Of Interest
- It proposed to discuss this matter under the sub headings of metabolism of nucleic acids (standing for polynucleotides, nucleotides, nucleosides, purines and pyrimidines), of proteins and ammo acids, ...
- Nucleic Acids. Part 2
- If one equates cell growth and division with the synthesis of DNA, it needs explaining why neoplastic cells appear to proceed in an irrepressible manner, as Potter indicated,108 with continuous DNA ...
- Nucleic Acids. Part 3
- As with purine analogues,188 184 anti-pyrimidines, such as 5-fluorouracil, are degraded by the neoplastic tissue much less readily than by normal tissues.130 Thus a reasonable case can be made out ...
- 2. Proteins and Amino-acids
- This is not the place to discuss details of protein biosynthesis and degradation, unless it has some bearing on the theme of this monograph. On the one side, proteins as histones and protamines are in...
- 3. Carbohydrate Metabolism
- Some aspects of deviations from normal tissues in the glycolytic and respiratory behaviour have been considered before, when the Warburg hypothesis was discussed, together with more recent contributio...
- 4. Enzymes in Lipid Metabolism
- The metabolism of the fourth main group of cellular constituents, namely fatty acids and fats, phospholipids, terpenoids and steroids (see reference 266), is closely linked with those of the other gro...
- 5. Coenzymes and Metal Co-factors
- It has been mentioned on several former occasions that in a few cases at least, the apparent deficiency in enzymic activity of neoplastic tissue could be caused by shortage of the required co-factors....
- Part II. How Can Enzyme Activities Be Influenced By Exogenous Means?
- Whether one accepts, on the basis of the survey just made, the view that alterations in enzyme activities are directly or indirectly connected with the development, establishment and progress of malig...
- 2. Metabolic Antagonism and Inhibition
- This represents rather a large chapter 287 and is based on the concept that agents produce biological effects by interfering with the action of naturally occurring, physiologically active compounds or...
- 2. Metabolic Antagonism and Inhibition. Continued
- One arrives now at what one could call generally coenzyme- or cofactor-antagonists. As these co-factors are in certain instances loosely, in others strongly bonded on to the apoenzyme, 'fraudulent' or...
- 3. Postulate for Restitution or Replacement
- Just as nutritional deficiencies which in the long run reflect unfavorably on metabolic and hence enzymic events in the body have been treated with vitamins, amino-acids, etc., and, as just noted, wit...
- Examples Of Enzymes And Coenzymes In Carcino-Chemotherapy
- In the following, a number of selected investigations are reported, together with the rationale why they were undertaken. They were mostly carried out with animals, and with the exception of one case,...
- 2. Ribonuclease And Deoxyribonuclease
- On previous pages it was pointed out that ribonuclease (a generic term referring in its experimental use to RNase of bovine pancreatic origin) might be lower in some malignant cells than in normal one...
- 3. Lipase
- The next example touches, in a chemical and functional sense, on properties of the surface or membrane of the cancer cell in comparison with those of homologous normal cells. After Coman74 had observe...
- 4. Model System For Cysteine Desulfhydrase
- This example represents an illustration for the possible use of a model enzyme in chemotherapy and at the same time for the postulate described in previous pages, namely of increasing catabolic proces...
- 5. Antagonism To Beta-Glucuronidase
- The last example refers to a kind of enzyme inhibition connected with a case of identifiable carcinogenesis in man. It will be remembered that -glucuronidase which catalyses the removal of glucu...
- Conclusions And Outlook
- An organism, whether plant, animal or man, can suffer lesions which if not inflicted by purely physical means, represent, generally speaking, biochemical lesions. In the case of poisons this may lead ...
- References
- 1. Abercrombie, M. and Ambrose, E. J.: Interference Microscope Studies of Cell Contacts in Tissue Culture. Exptl. Cell Res., 15 (2): 832, 1958. 2. Abrams, R. and Bentley, M.: Biosynthesis of Nuclei...
- References. Part 2
- 47. Brachet, J.: The Action of Ribonuclease on Living Amoebae. Exptl. Cell Res., 10: 255, 1956. 48. Brachet, J.: The Mode of Action of Ribonuclease on Living Root Tips. Biochem. Biophys. Acta, 19: ...
- References. Part 3
- 95. Fishman, W. H., Bonner, C. D. and Homburger, F.: Serum Prostatic Acid Phosphatase and Cancer of the Prostate. New England J. Med., 255: 925, 1956. 96. see Fishman, W. H., Green, S., Homburger, ...
- References. Part 4
- 146. see Kit, S.: The Role of the Hexose Monophosphate Shunt in Tumors and Lymphatic Tissues. Cancer Res., 16: 70, 1956. 147. Knox, W. E.: Two Mechanisms which increase in vivo Liver Tryptophan Per...
- References. Part 5
- 194. Pileri, A., Ledoux, L. and Vanderhaeghe, F.: Effets in vitro de la Ribonuclease sur les Cellules de la Moelle Osseuse et sur les Cellules d'Ascites du Carcinome de Landschutz. Biochim. Biophys. ...
- Glossary And Abbreviations
- Adenocarcinoma 7.5.5, a transplantable mammary carcinoma of the mouse. AMP, adenosine-5'-phosphate, adenylic acid. Anabolism, synthetic or building up processes, enzymically catalysed. Anaplasia...
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