The most important of the lesions included under the heading of skin cancer are epidermoid carcinoma (either squamous cell or basal cell) and melanoma. They are of particular significance to the practitioner because they are:

1. Common. This is particularly true in regard to the epidermoid variety which, in some parts of this country, is the most commonly encountered human cancer.

2. Accessible. Most of these lesions occur on exposed skin surfaces where they are readily detectable from their earliest beginnings.

3. Often misdiagnosed or mistreated. Frequently, because they are so readily observable and apparently innocuous in appearance, treatment is delayed -or is indequate or inappropriate.

4. Readily curable. Those lesions which make up the great bulk of skin cancers have curability rates of over 90%. For the relatively uncommon melanoma, of course, the outlook is considerably less promising but is far better than is generally realized if certain principles are observed.

5. Often preceded by premalignant lesions. In the case of the epidermoid lesion, these may take the form of certain keratoses of the so-called senile or other types. For melanomas, the junctional nevus is widely held to be the premalignant lesion.

6. Often preventable. Detection of and removal of premalignant lesions such as those mentioned previously will prevent their subsequent transformation into cancer. Also, etiologic or predisposing factors are known for a number of skin cancers. Avoidance or modification of exposure by individuals or groups to such diverse factors as excessive sunlight, radiation, and certain occupational hazards will prevent a significant amount of skin cancer.

Epidemiology. Incidence

Men

Women

41,000 new cases each year

25,000 new cases each year

2,200 Melanoma

1,300 Melanoma

38,800 Epidermoid carcinoma

23,700 Epidermoid carcinoma

15.9% of male cancer incidence

9.9% of female cancer incidence

Mortality

Men

Women

2,300 deaths each year

1,700 deaths each year

1,200 Melanoma

800 Melanoma

1,100 Epidermoid carcinoma

900 Epidermoid carcinoma

1.6% of male cancer mortality

1.4% of female cancer mortality

Rates And Ratios

Male

Female

Sex ratio

Incidence melanoma per 100,000

2.3

1.4

1.6 to 1

Incidence epidermoid cancer per 100,000

43.0

22.3

1.8 to 1

Mortality melanoma per 100,000

1.3

1.0

1.3 to 1

Mortality epidermoid cancer per 100,000

1.0

1.0

1 to 1

Trend Last Ten Years (All Skin Cancer)

Male

Female

Incidence-increase

21%

25%

Mortality

No significant change

Age (All Skin Cancer)

Male

Female

Significant increase beyond age

30

30

Over 15% of cases occur between ages

45-85

45-85

Geographic Distribution

There is an increased risk of epidermoid carcinoma in all geographic regions with prolonged exposure to sunshine. The highest reported rates are in Australia and in the white population of South Africa.