Allergic conditions, which as seen above, are related to the defense mechanism, also have been integrated into the general therapeutic approach. This has largely permitted us to apply to such conditions the same therapeutic measures used in general. The study of the manifestations has, however, shown that except for the anaphylactic shock, the clinical allergy corresponds to the prolonged phase with the predominance either of sterols or lipoacids. The urinary surface tension has appeared as a valuable criterion to indicate the occurring offbalance. In cases with a high urinary surface tension, sodium thiosulfate, aldehydes or epichlorohydrin have given particularly good results, while the cases with low surface tension showed favorable response to heptanol and butanol. Food allergies, asthma, urticaria which had persisted for years and were insufficiently influenced even by corticoids—have responded with the complete disappearance of their manifestations with an adequate dose of one or the other of the medications mentioned above. In most of the cases kept under continuous treatment with minimal doses, favorable results persisted even after the subjects were again under the influence of antigens. The following observations illustrate these results.

Mrs. M. S., 45 years old, with skin and eye allergic manifestations, highly sensitive for the past six years to fish, eggs, alcoholic beverages, some vegetables and fruits, and especially to dogs, showed no favorable response to corticoids. With high urinary surface tension and high eosinophiles, the patient was treated with 50 mg. sodium thiosulfate and 2 mg. epichlorohydrin, four times a day. The symptoms decreased progressively to disappear in a week. After a month's treatment, she was able to take—without any inconvenience—foods and alcohol to which she had been previously sensitive. After another two months, the acquisition of three puppies produced no disagreeable effects. The patient has continued on the same treatment, but reduced to twice a day, for the past year without recurrence of the manifestations.

Mr. A. L., 58 years old, had frequent attacks of asthma for over four and a half years which left him unable to work for the past year. Because of low urinary surface tension, the patient was put on butanol—5 cc. of a 6.5% solution in water—to be taken every six hours. Although the first doses showed marked objective and subjective changes, the treatment was continued. The patient was free of attacks for four months at which time he stopped medication. Two weeks after stopping medication, he had an attack, the first in four and a half months and this was followed by another the following day. By resuming the medication, he has been free of symptoms for more than a year.

The possibility of preventing allergic manifestations with butanol, which appeared so clear in the traumatic lesions, opens an entirely new view for many conditions where such a pathogenesis intervenes.

The concept of a nervous tissue allergy intervening in the pathogenesis of multiple sclerosis, led us to try similar antiallergic treatments. The low surface tension led us to utilize as agents, lipoids with a positive character. Interesting—although not constant—results were obtained with insaponifiable fraction of cow brain. Good results were obtained with butanol—100 mgr. four times a day—together with an antihistamine preparation.