The exceptionally good results obtained with mercaptans in treating cancer in humans could only partially be reproduced by the different agents with bivalent sulfur in the polar group we tested. In addition to the hydroper sulfides of the fatty acids, we tried to prepare and study other groups of persulfides. The great ability of the products of hydrogenization of naphthalene, such as tetrahydronaphthalene (tetralin) and dccahydro naphthalene (decalin) to fix oxygen as peroxides, led us to try to fix sulfur as persulfides on their molecules. These substances were treated with sulfur in conditions similar to those which led to fixation of sulfur to fatty acids. The agents obtained through this fixation on tetralin were particularly studied.

We have mentioned the pharmacological study of these products. Based on their biological action, they appeared to be intermediary between mercaptans and fatty acids persulfides, with the big advantage of having a bearable odor. In humans, we utilized this produce in cases of which, most are still under observation. In general, the results obtained were good.

Subjective changes and objective ones upon the tumors were obtained. We found that only minimal doses are to be used, corresponding to micrograms of sulfur and milligrams of tetralin. With these doses, no side effects were observed. When given slightly higher doses, some patients felt a sensation of weakness and also, in a few cases, of dizziness.

This agent has shown a marked influence upon the existing patterns with a special facility to induce, in most cases, an offbalance of type D at the cellular level. With higher doses, the systemic offbalance which is also influenced, can be changed back to offbalance type A only with difficulty. This fact indicates the need for reduced doses, acting almost exclusively at the cellular level. The dosage must be guided by a continuous control of the analyses, and especially by those of serum potassium for the cellular level and of urinary surface tension for the systemic. With values above 5 mEq potassium in serum (and low in blood red cells) and urinary surface tension of less than 68 dynes/cm., corresponding to a systemic offbalance of the type D, the decrease or even suppression of the medication is indicated.

We utilized the agent in cancer cases where the rapid disappearance of the tumor appeared as the capital aim. More time is needed to judge the value of those results already obtained. Among the cases treated, the following observation represents an interesting example.

B. P., 32 year old male, was operated for a wart at the right ear 2 1/2 years before coming under our care. Pathological examination had revealed malignant melanoma. A month later, a dissection of cervical glands was made. The analyses of the obtained glands showed no cancerous cells. Two months before coming under our care, a checkup revealed a new tumor in the right side of the larynx. With the growth of the tumor, edema of the right face was also increasing. Examination showed a tumor 4 cm. in diameter on the right side of the larynx. The tumor was adherent to the skin. Laryngological examination showed the tumor protruding in the pyriform sinus. Because extensive surgery would have been necessary for the tumor removal, the patient refused such surgery. He was admitted and first treated with only limited change in the tumor. Treatment was changed to tetralin persulfides in a dose of 10 drops of a 10% solution in oil, administered 3 times a day. Under this treatment, the tumor involuted very rapidly, and practically disappeared in 3 weeks. Subjective feeling, such as dizziness, made us discontinue the administration of the preparation. The treatment was changed to epichlorohydrin and sulfur in the form of fatty acid hydropersulfides, administered in small doses. The patient has continued this treatment at home for the past 2 1/2 years with no apparent recurrences.