In 1828 Hahnemann published his "Chronic Diseases," containing the symptomatology of a completely new series of medicines, a series of deeply-acting drugs, like Calcarea, Sulphur, etc., the so-called Anti-psoric remedies. The symptomatology of these remedies was not wholly pathogenetic, but included observations at the bedside, so-called clinical symptoms.

A second edition, greatly enlarged and now containing the symptomatology of twenty-five remedies, besides the twenty-two of the first edition, appeared between 1835 and 1839. A peculiar feature of the provings in this work is that the bulk of them must have been obtained with the thirtieth potency, and often are observations when given to the sick, differing entirely, therefore, from the pathogenetic effects of the Materia Medica Pura. A new English translation of this great work has just appeared in this country.

Besides Hahnemann and his immediate disciples, Constantine Hering, of Philadelphia, contributed the best provings to the homoeopathic Materia Medica, some of his drugs ranking in importance with Hahnemann's own. Of these, Lachesis, Glonoine and Apis take first rank.

Another large contributor to the Materia Medica was Dr. E. M. Hale, not so much by proving as by introducing American remedies that had been in use by botanic physicians, and gathering all that was known as to the therapeutic properties in one volume, called "New Remedies". We have, then, as Sources Of The Homoeopathic Materia Medica.

1. Hahnemann's Materia Medica Pura, published in 1811, containing the pathogenesis of the great poly-chrests - i. e., remedies of many uses and wide and frequent application.

2. Hahnemann's Chronic Diseases, published in 1828, containing the so-called Antipsoric remedies, those especially adapted to the cure of chronic diseases.

3. Dr. Jorg's Provings - a professor at the University of Leipsic and contemporary of Hahnemann, but not one of his followers. He proved, among others, Camphor, Digitalis, Opium, Arnica, Hydrocy. acid, Ignatia. Some of his symptoms are quoted and included by Hahnemann in the second edition of his works. .

4. Dr. Hering and the American Provers' Union.

5. Dr. E. M. Hale's contributions in his "New Remedies".

6. Various provings and reprovings under the auspices of the American Institute of Homoeopathy, various State societies and individual provings published in our journalistic literature. Also, Hartlaub and Trink's pathogeneses, Stapf's additions, provings by the Austrian Society, etc., etc.

These records are at present collected in three great works:

1. "Allen's Enclycopsedia," in ten volumes.

2. "Cyclopaedia of Drug Pathogenesy," in four volumes.

These two works contain the symptoms obtained by provings, and from records of poisoning, i. e., pathogenetic symptoms.

3. "Hering's Guiding Symptoms," in ten volumes, which also contains clinical or curative symptoms - i. e., observed on the sick.

The comparative value of the three sources of symptoms, from records of toxicology, provings on healthy and observation on sick.