Antipyrin depresses the temperature and suspends nerve sensation. Oft times gives rise to prostrating sweats, and is exceedingly erratic in its influence. Fortunately, its toxic influences are readily overcome by the use of brandy, strychnine, and heat. The utmost of conservatism should govern its administration, and one should bear in mind its many incompatibles. The dose ranges from I grain in children's diseases to the maximum of 30 grains for a robust adult. It should never be prescribed without keeping the patient under observation.