Guaiacol acts in a similar manner to creosote, but is more readily tolerated by the stomach. Dose, 2 111. gradually increased to 15 I., in pills, or in I or 20/0 solution in brandy, wine, or other vehicle, after meals. Guaiacolis carbonas (Duotol) is given in doses of 4 to 8 gr. in powder and gradually increased to 15 or 20 gr. Maximum dose, 90 gr. in twenty-four hours.