This section is from the book "A Practitioner's Handbook Of Materia Medica And Therapeutics", by Thos. S. Blair. Also available from Amazon: A Practitioner's handbook of Materia Medica and Therapeutics.
Sepia, Dried inky juice of cuttlefish. The ancients used a decoction of the cuttlefish for affections of the generative organs, urine, and skin. Hippocrates referred to it in his writings, and as long ago as Paracelsus it was known to influence what we know as the portal circulation; then Hahnemann dug it up from the old literature (as he did a great many other things) and limited its use to the inky juice in small closes. Sepia is used by artists as a water color. The alcoholic mother tincture is a disagreeable, rather oily substance with a taste of propylamine. I cannot find any authority for the statement, but I believe it does really contain that substance. Propyl amine and trimethylamine are supposedly isomeric. These substances are rather widely distributed. Cod-liver oil, shark-liver oil, herring brine, ergot, and several medicinal plants contain it. While possessed of the same number of atoms, these various amines have differing graphic formulae and quite different properties. Trimethylamine has a more or less established place in therapeutics, being used in rheumatism and chorea. Some authorities consider the trimethylamine content of ergot quite an important factor in its therapy. It is known, in some of its combinations, to markedly influence the circulation. It is, therefore, altogether likely that if sepia contains it, as most visceral fish products do, it would have an influence upon the circulation, and probably also upon the womb. More definite statements would be rash, in view of the present lack of data.
The homeopaths must get some action from it, since they esteem it most highly. Their detailed provings or symptoms of this drug are elaborate, but amount to about this: Indicated in hepatic and venous congestion in lower abdominal and pelvic regions, with yellow spots upon face; flushes of heat, nausea, flatulence, yellow or greenish leucorrhea, and a marked bearing-down sensation. Personal experience is sadly wanting, but I am inclined to think there is something worth while in this remedy. I bought a quantity of the 2x tablet triturates, and used only in cases of leucorrhea of the character indicated. Upon the whole, the results were good. Some of the eclectics use it, contending that it does not act according to the "similia" idea, but is of value, as indicated above, in uterine and liver troubles. Very probably, the homeopaths overrate the value of sepia.