This variety generally first manifests itself in the lower extremities, especially after standing or walking, gradually extending upwards, until the cellular tissue of the whole system becomes involved. The swelling is generally soft and doughy, leaving a dent on pressure, and the skin white and shining. When confined to the lower extremities, it may exist for years with but little danger, but it seldom pervades the whole system, unless the system has become seriously impaired.

Causes

It is frequently produced by abuse of Arsenic and Mercury. Loss of blood, abuse of stimulants, derangement of the womb, scarlatina, measles, pulmonary consumption, etc.