Derivation

Glycozone is composed of chemically pure glycerine and peroxide of hydrogen. When these two preparations are combined, the result is a stable compound owing to the reaction that takes place when chemically pure glycerine is submitted, under certain conditions, to the action of fifteen times its own volume of ozone, under normal atmospheric pressure at a temperature of 0° C. The glycerine thus employed must be chemically pure, as the pressure of the water or other foreign matter in it produces in the resulting compound formic acid, glyceric acid, and other secondary products that have an injurious effect on animal tissue. Glycozone possesses a pleasant, sweetish taste, and causes a feeling of warmth when it comes in contact with the mouth or stomach.

Medical Properties and Action - Glycozone excites the salivary glands to increased action and stimulates the gastric secretions. It attracts to itself water from the adjacent tissues, but not sufficient to cause injury, a property due to the glycerine it contains. In excessive doses of one or two ounces, glycozone causes epigastric uneasiness, followed by loose, copious, watery stools, which are accompanied by severe cramps. It appears to have no effect upon the kidneys, liver or heart. It is slowly decomposed in the stomach, ozone being liberated and the glycerine uniting with the water from the tissues. It is supposed that the morbid elements with which it comes in contact hasten this decomposition, and in so doing are themselves oxidized and destroyed. The presence of free ozone in the stomach resulting from the decomposition of glycozone aids the digestive process. Glycozone must be kept in tightly-corked bottles, glass-stoppered are best, and when thus protected, it will not deteriorate at a temperature of even 110° F. No metallic instruments should be brought in contact with it, as such contact decomposes it; hence glass or hard-rubber vessels and syringes are necessary when using it. It resembles peroxide of hydrogen in producing a powerful oxidizing effect, although its action may not be as rapid or as energetic as the latter compound; therefore it cannot be safely combined with other drugs or chemical substances when prescribing it.

Therapeutic Uses

Glycozone is employed in the treatment of gastric ulcer, affections of the stomach, catarrh of chronic alcoholism, chronic gastric catarrh from other causes, and atonic and acid dyspepsia. Externally - when a diseased or suppurating surface is cleansed by peroxide of hydrogen, the application of glycozone stimulates healthy action and promotes recovery. It also checks the discharge of irritating secretions, and prevents infection from pathogenic organisms, by acting as a powerful antiseptic and stimulant. It is also useful in follicular pharyngitis, and chronic coryza, and croup.

For diphtheria a tablespoonful of glycozone may be given in 27 a wine-glassful of water every three hours with excellent effects; it is harmless. For membranous croup, after spraying the nose, throat, larynx and pharynx copiously every two hours or so with a mixture of peroxide of hydrogen with 4 to 6 ounces of water, the membranes are destroyed, and then one teaspoonful of gly-cozone, diluted in a wine-glass of water and given three times a day, will prevent any disturbance of the stomach, and will regulate the bowels. In ulceration and chronic inflammation of the intestines, great benefit is derived from enemata consisting of glycozone Therapeutic Uses 1072 and lukewarm water prepared just before using; also in fistula-in-ano and rectal ulcerations glycozone and lukewarm water administered once or twice daily, will produce good results. For leucorrhoea, the vagina is first washed with peroxide of hydrogen one part and water four parts, when glycozone is applied on small rolls of lint, or absorbent cotton, and the procedure repeated twice daily.

Dental Uses

Glycozone is employed for all forms of inflammation and ulceration of the oral mucous membrane, and in ulcerative stomatitis frequent applications prove very beneficial. It is also considered to be useful in the chronic form of alveolar abscess in the form of an injection composed of glycozone and lukewarm water.