In simple soft goitre, in which malady, indeed, the reputation of iodine was first acquired, I consider it almost a specific. In recent cases, 1 to 5 min. doses of the tincture produce the best results, for, if unduly large quantities be given, the swelling becomes hard, tender, and painful. In more chronic cases already indurated, large doses- 1/4 to 1 gr. of iodine - may be given in conjunction with its external use (v. p. 71); some astringent syrup, e.g., of cinchona or orange-peel, should be added to prevent derangement of stomach. Mr. Bryant has known goitres rapidly disappear under the influence of an iodized atmosphere, obtained by simply placing iodine in a perforated box in the patient's room; he recommends also the local use of an ointment of iodide of ammonium ("Practical Surgery," 3d Ed.).

In Exophthalmic Goitre I have also seen a limited amount of success from the internal use of iodine tincture, the palpitation being frequently relieved by small doses.