When this occurs, independently of distinct gouty attacks, lithia salts, amply diluted, often act well, rendering the "gravel" soluble and the urine clear. According to the observations of G. de Mussy and others, the bromide of lithia exerts a high degree of solvent or lithontriptic power (Roubaud: Archives Gen., 1875).

Lithiated injections into the bladder for direct solution of uric concretions were proposed by A. Ure and Aschenbrennen. The former observer ascertained that an oxaluric calculus placed in a 4-gr. warm solution of a lithia salt lost 5 gr. in weight in five hours, but his practical application of this knowledge to the treatment of calculus within the living bladder has not proved very satisfactory. The patient got some temporary relief from the lithiated injections, and they were presumed to have softened the calculus, but did not reduce its size. Lithotrity was performed, but ultimately the man died (Lancet, ii., 1860). Mr. Ure directs attention to the necessity of avoiding lithia when phosphate of soda is present in the urine, otherwise an insoluble triple phosphate is formed.