This section is from the book "Materia Medica And Therapeutics: An Introduction to the National Treatment of Disease", by John Mitchell Bruce. Also available from Amazon: The pharmacology and therapeutics of the materia medica.
The flowering herb of Lac-tuca virosa. a native of Britain.
Composition.-Extract of lettuce contains, besides many other ingredients, a crystalline bitter principle, lactucin, and lactucic acid, of uncertain composition.
Preparation.
Extractum Lactucae.-A green extract. 1 1/2 in 1. Dose, 5 to 10 gr.
Lactucin is slightly hypnotic. The extract may cause some confusion of mind, headache, and diaphoresis ; and acting as a mild sedative and carminative, it makes an excellent pill-basis for some purgatives, such as calomel.
 
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