This salt (hydrastinince hydrochloridum), C11H11No2.HCl, is the hydrochloride of an artificial alkaloid formed by the oxidation of hydrastine. Dose, 1/2 grain (0.03 gm.). It is freely soluble in water and alcohol. Hydrastinine has a local constricting effect on arteries, and has the same action on centers as hydrastine; but it has little if any effect in depressing the heart and other muscles. It induces a rise in blood-pressure through stimulation of the vasoconstrictor center. It causes rapid dilatation of the pupil, the effect wearing off inside of twenty-four hours.

It is for its action on the uterus, however, that hydrastinine is employed, as it tends to stop hemorrhage by stimulating the uterus itself. It is not so good as ergot in postpartum hemorrhage, but is largely employed in subinvolution, in late hemorrhage following parturition, and in profuse menstruation, whether caused by fibroids or not. A 10 per cent. solution has been employed locally on cotton in hemorrhage from nose, mouth, rectum, and uterus.

Cotarnine hydrochloride, stypticin, is oxymethyl-hydrastinine; dose, 1/2 grain (0.03 gm.). It is prepared from narcotine, and has an action practically like that of hydrastinine, but with a hydras-tine tendency to depress the heart muscles, and a mild narcotic action. Its uses are those of hydrastinine.