Benzosulphinide (saccharin, gluside, C6H4So2.Conh) is an acid anhydride soluble in 290 parts of water and 31 of alcohol. Sodium-benzosulphinide (sodium-saccharin) is soluble in 1.2 of water and 50 of alcohol. The U. S. P. states that an aqueous solution of 1 in 10,000 has a sweetness comparable with a 1 in 20 solution of sugar, i. e., it is 500 times as sweet. But it has a flavor which is not so pleasing as that of sugar. It has been much employed in chewing gum, chewing tobacco, soda-water and canned foods as it is slightly antiseptic and is not fermentable; but it is not a food and lacks the caloric value of the sugar for which it is substituted.

Mathews and McGuigan considered it deterrent in digestion by ptyalin, pepsin, and trypsin, but Roger and Garnier found that the acid anhydride activated pepsin mildly in the same way as hydrochloric acid. In amounts of not over 5 grains (0.3 gm.) a day for normal adults it Was pronounced harmless by the U. S. Referee Board of Chemists, and Folin, a member of the Referee Board, said of their experiments, "The negative character of the results obtained indicates that saccharin in moderate doses is not injurious to the health of normal sound adults." Mercier took 75 grains a day (5 gm.) for 14 days without harm. Furthermore, the extensive use of the drug by diabetics has not brought out any deleterious effects. The lethal dose for a rabbit is in excess of 2 1/2 drams (10 gm.) and it is rapidly eliminated by the kidneys in unchanged form. In medicine it is employed as a sweetening agent for the use of diabetics and the obese, and in infants' or children's food when it is desired to omit sugar, as in the "sugar susceptibles" of Kerley. One grain (0.06 gm.) of sodium-saccharin is employed in place of a tablespoonful of sugar.