This section is from the book "Materia Medica Pharmacy, Pharmacology And Therapeutics", by W. Hale White. Also available from Amazon: Materia Medica Pharmacy, Pharmacology And Therapeutics..
B. P., not official. - Cusparia Bark. Synonym. - Angustura Bark. The bark of Cusparia febrifuga (nat. ord. Rutaceae).
Tropical South America.
Flat or curved pieces or quills, 16 cm. or less long, 4 mm. thick, obliquely cut on the inner edge. Externally a yellowish-gray, mottled, corky layer, which can be scraped off, and shows a dark brown resinous layer; inner surface light brown, flaky. Fracture short, resinous, and showing, under a lens, white points or lines. Taste bitter, aromatic. Odor musty, disagreeable. Resembling Cusparia. - Canella Alba, but this is darker, and has pared edges.
The chief constituents are - (1) Cusparine, or Angustu-rine, a crystalline bitter alkaloid. (2) An alkaloid, Galipeine. (3) An alkaloid, Galipidine. (4) An alkaloid, Cusparidine. (5) An aromatic oil. It is stated that no Tannic Acid is present, but Iron Salts are incompatible with Cusparia.
Incompatibles. - Mineral acids and metallic salts.
Dose, 10 to 40 gr.; .60 to 2.40 gm.
Infusum Cuspariae. B. P., not official. - Infusion of Cusparia, Cusparia, 5; Water at 120o F.; 48.80 C (to avoid extraction of nauseous principles), 100.
Dose, 1 to 2 fl. oz.; 30. to 60. c.c.
Cusparia bark is an aromatic bitter, having a similar action to calumba. It is used to make Angustura Bitters. In South America it is given in large doses as an antiperiodic.